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Pattern recognition of viral nucleic acids by RIG-I-like helicases
Schematic representation of the viral RNA sensors RIG-I, MDA-5 and LGP2. . not find evidence for RIG-I activation by ligands bearing monophosphates, independently of the status of base .. Science 323(5917):1070 1074CrossRefPubMed.
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DDX58 is an RNA helicase that belongs to the DEAD/H box family. does not generate dsRNA and that RIGI is activated by viral genomic single-stranded RNA (ssRNA) bearing 5-prime-phosphates. This is .. Science 323: 1070-1074, 2009.
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1 Apr 2011 RT-PCR was performed on RNA isolated from HeLa cells .. For all recombinant proteins except GST RPA-194, BL21(DE3)pLysS bearing the respective expression vectors was .. E10-08-0731v1; 22/7/1070 most recent
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To define the roles of FcR-bearing hemopoietic cells and of kidney resident mesangial cells in pathogenesis, (NZB .. Tg MC did not express detectable FcR at the RNA level neither in the resting state .. 164: 1065 1070. 25. Kaplan, C. D.
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26 Apr 2010 bearing amino-terminal cleavable signal peptides (Blobel and Dobberstein, 1975) and . 2010 Blackwell Publishing Ltd, Molecular Microbiology, 76, 1070 1081 The DEAD-box protein family of RNA helicases. Gene 367:.
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Molecular Mechanics of RNA Translocases
23 Apr 2015 Historically, research on RNA helicase and translocation enzymes has seemed like a .. it binds with the tightest affinity to duplexed substrates bearing a triphosphate group (Wang et al., 2010). .. 2009;323:1070 1074.
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Activation of MDA5 Requires Higher-Order RNA Structures pdf
16 Apr 2009 MDA5 is activated by long molecules of double-stranded RNA (dsRNA) produced by annealing of comple- mentary RNAs . but also RNA of high molecular weight (HMW) bearing both Science 323:1070 1074. 20.
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The Ras/PKA Signaling Pathway May Control RNA Polymerase II
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interaction with the corresponding DNA or RNA in a FRET- substrate bearing Cy3 or DY547 fluorophore was visualized as .. RNA. Science 323:1070 1074.
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RIG-I ATPase Activity and Discrimination of Self-RNA versus Non
3 Mar 2015 Many RNA viruses are detected by retinoic acid-inducible gene i a stretch of double-stranded RNA (dsRNA) bearing a base-paired 5′ ppp nucleotide. Science 323:1070 1074. doi:.10.1126/science.1168352 [PMC free
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